N for an Alcoholic

[OldDrummer]

I've been a heavy drinker for the past 20 years - roughly about 2-3 bottles of white wine an evening.

Would 200mg N be effective for me? I'm 250 pounds and 5'10.

 

[bad luck]

That's what I would like to know. I've been a heavy drinker, I don't drink every day and I can go weeks without drinking, but I think I have a high tolerance. For example, yesterday I drank 3 liters of strong beer (7 degrees) in just over 2 hours. Weight 90kg.

In a quick glance I've read that alcoholics need a higher dose but I haven't found anything.

I'm only going to save for 2 bottles (200ml) and I hope it's enough...

 

[suicidesheep31]

I dont know. But the receptor in the brain for alcohol and for N are different.
For alcohol, this is the GABA receptor and For N this is the opiod receptor.
Alcohol should not reduce the action of N on the receptor levvel.

 

[OldDrummer]

I dont know. But the receptor in the brain for alcohol and for N are different.
For alcohol, this is the GABA receptor and For N this is the opiod receptor.
Alcohol should not reduce the action of N on the receptor levvel.

True, but the issue is how the liver processes the N.

 

[watchingthewheels]

Per the PPH:

"In some of the analyzed cases, the long comatose phase was associated with the prolonged use of anti-psychotic medication or chronic heavy alcohol use, prior to taking the barbiturate. It is presumed the induction of liver enzymes by these drugs causes increased degradation of the Nembutal, lowering the concentration in the brain. In these situations, increasing the quantity of drug taken (eg. to 2 bottles, 12gm) may not necessarily hasten the death."

 

[bad luck]

Per the PPH:

"In some of the analyzed cases, the long comatose phase was associated with the prolonged use of anti-psychotic medication or chronic heavy alcohol use, prior to taking the barbiturate. It is presumed the induction of liver enzymes by these drugs causes increased degradation of the Nembutal, lowering the concentration in the brain. In these situations, increasing the quantity of drug taken (eg. to 2 bottles, 12gm) may not necessarily hasten the death."

Thank you: that would mean that they would die the same but later

 

[Sunset Limited]

I dont know. But the receptor in the brain for alcohol and for N are different.
For alcohol, this is the GABA receptor and For N this is the opiod receptor.
Alcohol should not reduce the action of N on the receptor levvel.

All barbiturates are to some extent GABA A agonists. In particular, pentobarbital is a more potent GABA A receptor agonist than phenobarbital. However, since pentobarbital is an overall non-selective CNS depressant, I do not think alcohol dependence will change the outcome in any way. What makes pentobarbital an ideal euthanasia drug is that it shuts down consciousness before its deadly effects. That is, consciousness turns off before breathing stops. If someone is addicted to alcohol, does it take longer to lose consciousness? I don't think so because the amount of N used for euthanasia is a large dose far beyond any scientific study.

 

[watchingthewheels]

All barbiturates are to some extent GABA A agonists. In particular, pentobarbital is a more potent GABA A receptor agonist than phenobarbital. However, since pentobarbital is an overall non-selective CNS depressant, I do not think alcohol dependence will change the outcome in any way. What makes pentobarbital an ideal euthanasia drug is that it shuts down consciousness before its deadly effects. That is, consciousness turns off before breathing stops. If someone is addicted to alcohol, does it take longer to lose consciousness? I don't think so because the amount of N used for euthanasia is a large dose far beyond any scientific study.

But there's still the matter of factoring in the liver enzymes having an effect on the proces (as explained in the PPH), no ?
(Unfortunately, it doesn't specify whether or not the delay caused by liver damage includes lengthening the onset of unconsciousness vs. time of death...)

 

[Sunset Limited]

But there's still the matter of factoring in the liver enzymes having an effect on the proces (as explained in the PPH), no ?
(Unfortunately, it doesn't specify whether or not the delay caused by liver damage includes lengthening the onset of unconsciousness vs. time of death...)

It is known from clinical studies that the dose of propofol required to induce general anesthesia in chronic alcohol addicts is higher than in non-addicted patients. I don't think there has been such a study with N because it is not used as a general anesthetic. Therefore, it is necessary to rely on data from the euthanasia of alcohol abusers. It may increase the time required for the onset of unconsciousness, but I don't think it will significantly alter the overall score on the peacefulness of euthanasia. Still, if I was addicted to alcohol, I would go with 2 bottles.

 

[Tamara Tami]

All barbiturates are to some extent GABA A agonists. In particular, pentobarbital is a more potent GABA A receptor agonist than phenobarbital. However, since pentobarbital is an overall non-selective CNS depressant, I do not think alcohol dependence will change the outcome in any way. What makes pentobarbital an ideal euthanasia drug is that it shuts down consciousness before its deadly effects. That is, consciousness turns off before breathing stops. If someone is addicted to alcohol, does it take longer to lose consciousness? I don't think so because the amount of N used for euthanasia is a large dose far beyond any scientific study.

@Dystopia @PerpetualPain @Sunset Limited 1 propofol is agonist of A or B or both receptors? 2 do you know if propofol penetrates the presynapse membrane of the neuron with out require to bind to Gaba receptors?