N and Rx Interactions

[BrokenBliss]

Has anyone read anything about prescriptions interfering with the effectiveness of N? I, for example, have been taking pain killers for years in order to survive my life with severe neuropathic pain and nerve damage.

 

[WhiteRabbit]

Has anyone read anything about issues with prescriptions interfering with the effectiveness of N? I, for example, have been taking pain killers for years in order to survive my life with severe neuropathic pain and nerve damage.

I haven't heard that opiates or anything like that interfere with the effectiveness. I take opiates and Lyrica and I plan to ctb with N.

Sorry about your neuropathy, I suffer from it as well.

 

[BrokenBliss]

I haven't heard that opiates or anything like that interfere with the effectiveness. I take opiates and Lyrica and I plan to ctb with N.

Sorry about your neuropathy, I suffer from it as well.

So sorry. It's brutal, I know.

 

[tryingtoescape]

Would N interact with Lamictal at all? I am on 600 mg of Lamictal. I need to take it or I have constant panic attacks so bad I vomit, even if I stop for a day. Certain AEDs often drastically reduce the level of other drugs and other gaba increasing drugs, like Tegretol reducing benzodiazepine concentration by up to 80%. Because some are enzyme inducers, some inhibitors, depending on the enzymes they affect. They are both metabolized by the liver so this is very crucial and this all depends on the enzymes they effect.
I can't find any information online about interaction between Lamictal and N, but I'm worried, because N isn't used anymore so it may be undiscovered. I've been trying to do research on what enzyme it effects and which enzyme N is in the liver, which would make it clear, but I can't find information.
Like Tegretol, for example, would totally reduce the volume of N, and Lamictal and Tegretol are in the same class (anticonvulsants) but they effect different enzymes. But I want to make sure.

Lamictal can also cause liver damage in high doses. This would affect N. I am currently on 600 mg because I'm on estrogen pills for severe acne and estrogen reduces the levels of Lamictal by half. I don't understand if the 600 mg is absorbed by liver when estrogen reduces the blood concentration of it. Elevated liver enzymes are a cause of extended coma in N suicides. I cant take N with elevated liver enzymes, which high doses of Lamictal can rarely cause, but I don't know if this is a risk because I don't know if the full Lamictal dose or half is still absorbed by the liver with the estrogen.

Is anyone who is taking N on Lamictal? Or have info or understanding of chemical interactions between them?