Discussion Medication/Substance Thread

[uselessmanz]

Another bump for today (23)

What's a bump?

 

[NameOfAction]

What's a bump?

 

[GhostCat25]

Hi Mati!

Thank you so much for doing this for the community. I appreciate your vast knowledge and reading everything has been very helpful.

I was hoping you could help me with Benzo substitute. I read that Z-drugs can be used as substitute and I managed to obtain 30 tablets of Zopiclone (7.5mg).

In the PPEH procedure, they recommended to "Crush 20x30mg tablets (Oxazepam) (Benzos)". Since there's no calculator that directly converts Benzos to Z-drug.

If possible, could you estimate what is the equivalent for Zopiclone (7.5mg)?

Thanks in advance!

 

[bittersweetly]

How much Amitriptyline should i take to die?

 

[MatiSendiri]

Another long college delays, so here goes nothing:

What would happen if I took two to three bottles of flexeril? Is there risk of serotonin syndrome? What if I mixed it with olanzapine?

I have some old amitriptyline but I hear that's slow and painful, probably would need more than I have.
Do you know anything about iatrogenic injury from medication? I feel like olanzapine really screwed me over in many ways.

1. I do not think its worth it using Flexeril (Cyclobenzprine) to ctb. While there are recorded cases of ctb using it (1), not a lot of the cases reported have success rate compared to other drugs. Many reported cases ended up successfully resuscitated after nearly fatal intoxication (2,3,4). I do think you can pass away when taking 2-3 bottles of it, especially added with olanzapine. The biggest question is how you ingest all of them though...
2. See my replies on @Porgierot on amitryptiline deaths
3. I think it'd be better know as adverse effects of the medication. What AE did you experience with olanzapine?

I've had some attempts with amitriptyline, though they were fairly impulsive and I ended up panicking myself out of them. Entered coma both times, I'm curious about the painfulness as I haven't ever seen that much talk about it at all nor heard from a lot of others on it. When would that pain come? Would such a coma just continue til you die or are you likely to wake up at some point and be in pain? I've been told my previous 2.5g dose was likely to kill me if I hadn't been in the hospital and I have more than double of it now if I end up giving it a better try, but very curious about the pain mentioned as I wasn't in pain when I ODed on them.

I don't know much about the painfulness of Amitriptyline overdose. All the reports I have seen usually describe usual signs of toxicity such as agitation, mental confusion, or somnolescence. Furthermore, since amitriptyline affects the heart immidiately, oftentimes you may have been unconscious first before you experience the pain.

For further reading on amitriptyline or TCA overdose, I'd recommend this paper by European PMC. For fatal cases, you can read this one.

Hi Mati!

Thank you so much for doing this for the community. I appreciate your vast knowledge and reading everything has been very helpful.

I was hoping you could help me with Benzo substitute. I read that Z-drugs can be used as substitute and I managed to obtain 30 tablets of Zopiclone (7.5mg).

In the PPEH procedure, they recommended to "Crush 20x30mg tablets (Oxazepam) (Benzos)". Since there's no calculator that directly converts Benzos to Z-drug.

If possible, could you estimate what is the equivalent for Zopiclone (7.5mg)?

Thanks in advance!

Since the purpose of the benzo in PPEH is to only knock you down/making you unconscious, I think its far more easy to search the comparison of both in insomnia. This paper compares both benzodiazepine (it is implied the benzos here are short acting ones, such as oxazepam and alprazolam) with Z-drugs. It has been found that benzo is 10-40x have more myorelaxant effects compared to Z-drugs. You can also read more with this paper too. Here's my recommendations:
1. Found out your personal dose of Z-drugs to knock yourself ASAP (preferably 15-30 minutes after ingestion). This is far more better than using general advice on benzo like on PPEH. You can start at the minimal dose every night and then increase it steadily. You can record yourself on to sleep after ingesting them and compare them later to found out your optimal dose is
2. On your ctb attempt, combine that optimal dose with alcohol to make sure they interact better.

How much Amitriptyline should i take to die?

Around 8-10 g according to PPEH. Another paper says that amitriptyline serious toxicity dose varies between 10 and 30 mg/kg in adults.

 

[MatiSendiri]

Another bump for today (28)

 

[Nolongerlive]

What about bisoprolol fumarate ? Is 250 mg dose enough ?
if not, how about combining with amitriptyline or digoxin ?

 

[MatiSendiri]

What about bisoprolol fumarate ? Is 250 mg dose enough ?
if not, how about combining with amitriptyline or digoxin ?

1. I think that's enough to kill you, but it's still painful and long. If you want to die using bisoprolol only, I'd recommend combining it with other methods such as this one with drowning. You can read more about bisoprolol (or any other beta blockers drugs) here

2. You can combine it with amitriptyline or digoxin, but at that point just follow PPEH man

 

[Nolongerlive]

1. I think that's enough to kill you, but it's still painful and long. If you want to die using bisoprolol only, I'd recommend combining it with other methods such as this one with drowning. You can read more about bisoprolol (or any other beta blockers drugs) here

2. You can combine it with amitriptyline or digoxin, but at that point just follow PPEH man

Thank for your reply.

I wish i can get more of other stuffs , but i am from a very controlled country. In fact, i dont even sure i can get amitriptyline or digoxin into the country.

 

[m1v]

Hi, I was told in the past that the research chemical Methymetaqualone (mmq) was letal via this thread. Do you agree? Will 1g of Methymethaqualone, 25mg of Rilmazafone & 12mg of Bretazenil take me away? (If i were to take it all orally by the way, in capsules)

I heard that mmq seizures are almost unavoidable , so then im not 100% sure if its going to be peaceful even with the help of anticonvulsants.

 

[MatiSendiri]

Hi, I was told in the past that the research chemical Methymetaqualone (mmq) was letal via this thread. Do you agree? Will 1g of Methymethaqualone, 25mg of Rilmazafone & 12mg of Bretazenil take me away? (If i were to take it all orally by the way, in capsules)

I heard that mmq seizures are almost unavoidable , so then im not 100% sure if its going to be peaceful even with the help of anticonvulsants.

To be honest, all of your drug is newly discovered and didn't have complete data, especially about it's toxicity. I bet that'll work for ctb, but man Idk if that'll be long or not.

Sorry I can't answer this man

 

[bugbugbug]

If I am unable to get the usual antiemetic metoclopramide, do you have an over the counter recommendation? (I'm US based I'm not sure if this would impact your answer)

 

[barleybarley]

Hi sorry I'm new to the website and am having trouble navigating it. I have a good doctor who tries me out on different stuff regularly, including trying old shit they used to do. It's def improved my quality of life just leaning into it enough for them to try whatever and see the results. I'm gonna ruin my own life, feels better to let my doctors what my life get ruined by their own hands and try their best to fix it best they can. They've already extended my life by at least a decade and most everyone would say that way worth it already, makes me curious about the future.

 

[MatiSendiri]

If I am unable to get the usual antiemetic metoclopramide, do you have an over the counter recommendation? (I'm US based I'm not sure if this would impact your answer)

There are a few options for you:
1. Ondansetron, this is basically an substitute for metoclopramide.
2. Scopolamine
3. Antihistamines at large doses. Do note that some of these are deliriant (such as DPH) so make it as your last option

I don't really recommend other type of drugs that can be an antiemetic since it's kinda wonky. If you want to read more about this you can start here

Hi sorry I'm new to the website and am having trouble navigating it. I have a good doctor who tries me out on different stuff regularly, including trying old shit they used to do. It's def improved my quality of life just leaning into it enough for them to try whatever and see the results. I'm gonna ruin my own life, feels better to let my doctors what my life get ruined by their own hands and try their best to fix it best they can. They've already extended my life by at least a decade and most everyone would say that way worth it already, makes me curious about the future.

So sorry for your condition man. Hope it'll be better soon

 

[bugbugbug]

There are a few options for you:
1. Ondansetron, this is basically an substitute for metoclopramide.
2. Scopolamine
3. Antihistamines at large doses. Do note that some of these are deliriant (such as DPH) so make it as your last option

I don't really recommend other type of drugs that can be an antiemetic since it's kinda wonky. If you want to read more about this you can start here

So sorry for your condition man. Hope it'll be better soon

I apologize for the quick follow up, from what I'm seeing there isn't a non-prescription option?

 

[MatiSendiri]

I apologize for the quick follow up, from what I'm seeing there isn't a non-prescription option?

Oh sorry about that. Here's a list of non-prescription antiemetics that you can buy



Source: Handbook of Non-prescription Drugs

Basically most of non-prescription antiemetics is an antihistamine drugs. My recommendation is to use dimenhydrinate.

 

[MatiSendiri]

Another bump for today (29)

 

[GhostCat25]

Another long college delays, so here goes nothing:


1. I do not think its worth it using Flexeril (Cyclobenzprine) to ctb. While there are recorded cases of ctb using it (1), not a lot of the cases reported have success rate compared to other drugs. Many reported cases ended up successfully resuscitated after nearly fatal intoxication (2,3,4). I do think you can pass away when taking 2-3 bottles of it, especially added with olanzapine. The biggest question is how you ingest all of them though...
2. See my replies on @Porgierot on amitryptiline deaths
3. I think it'd be better know as adverse effects of the medication. What AE did you experience with olanzapine?


I don't know much about the painfulness of Amitriptyline overdose. All the reports I have seen usually describe usual signs of toxicity such as agitation, mental confusion, or somnolescence. Furthermore, since amitriptyline affects the heart immidiately, oftentimes you may have been unconscious first before you experience the pain.

For further reading on amitriptyline or TCA overdose, I'd recommend this paper by European PMC. For fatal cases, you can read this one.

Since the purpose of the benzo in PPEH is to only knock you down/making you unconscious, I think its far more easy to search the comparison of both in insomnia. This paper compares both benzodiazepine (it is implied the benzos here are short acting ones, such as oxazepam and alprazolam) with Z-drugs. It has been found that benzo is 10-40x have more myorelaxant effects compared to Z-drugs. You can also read more with this paper too. Here's my recommendations:
1. Found out your personal dose of Z-drugs to knock yourself ASAP (preferably 15-30 minutes after ingestion). This is far more better than using general advice on benzo like on PPEH. You can start at the minimal dose every night and then increase it steadily. You can record yourself on to sleep after ingesting them and compare them later to found out your optimal dose is
2. On your ctb attempt, combine that optimal dose with alcohol to make sure they interact better.


Around 8-10 g according to PPEH. Another paper says that amitriptyline serious toxicity dose varies between 10 and 30 mg/kg in adults.

Thank you so much for your reply!

It was very helpful. I've been doing personal dose trials and timed myself on Zopiclone. It's super strong and knocks me out within ~30 minutes or so. However, I've had issues with blacking out or sleeping "walking/doing" things like texting people, letting my cat out without me knowing, sending things via texts. All of which I don't recall...

It's all harmless things so I hope when it comes to my CTB date, that I don't butcher it with sleepwalking

Thanks once again!

 

[MatiSendiri]

Another bump for today (30)

 

[LittleJem]

How do I make cyanide? Id rather injest it. Is it posdible to grund up abricot kernals, how many, and would aomeome vomit yjem up? Is encapsulation an option?

Thank you and best wishes

 

[MatiSendiri]

How do I make cyanide? Id rather injest it. Is it posdible to grund up abricot kernals, how many, and would aomeome vomit yjem up? Is encapsulation an option?

Thank you and best wishes

I was surprised this method exists tbh. Apparently you can get cyanide poisoning using apricot kernels. If you want to read more you can use this paper.

However there are numerous caveat here:
1. No recorded cases of fatalities from cyanide in apricot kernels
2. No data how much you can eat apricot kernels before if you throw up
3. Cyanide content in apricot kernels varies so much
4. You don't really know how much cyanide could kill you, especially from apricot kernels

So the summary is you kinda can die using apricot kernels, but just use other method please.

 

[StoneCactus]

I was surprised this method exists tbh. Apparently you can get cyanide poisoning using apricot kernels. If you want to read more you can use this paper.

However there are numerous caveat here:
1. No recorded cases of fatalities from cyanide in apricot kernels
2. No data how much you can eat apricot kernels before if you throw up
3. Cyanide content in apricot kernels varies so much
4. You don't really know how much cyanide could kill you, especially from apricot kernels

So the summary is you kinda can die using apricot kernels, but just use other method please.

There's an easy to find online vendor that sells amygdalin (the poisonous component in apricot kernels and bitter almonds) to consumers. There are a few case studies where people took amygdalin in moderate quantities together with Vitamin C and needed to go to the ICU (and presumably would have died without treatment) Would that be more effective than just acorn kernels by themselves, since you have a reasonable assurance of ingesting enough of the active ingredient?

 

[MatiSendiri]

There's an easy to find online vendor that sells amygdalin (the poisonous component in apricot kernels and bitter almonds) to consumers. There are a few case studies where people took amygdalin in moderate quantities together with Vitamin C and needed to go to the ICU (and presumably would have died without treatment) Would that be more effective than just acorn kernels by themselves, since you have a reasonable assurance of ingesting enough of the active ingredient?

Amygdalin and Vitamin C combination is seriously fatal and underrated methods tbh. Oral intake of 500 mg of amygdalin may contain as much as 30 mg of cyanide according to this paper. You may need as little as 1 gram of pure amygdalin taken orally combined with vitamin C to create 60 mg of cyanide, which is in the lethal dosage of cyanide itself. You can read more in here and here.

I'd highly recommend to use both pure amygdalin and vitamin C to maximize this interaction rather than using amygdalin from acorn kernels. Do note that vitamin C is irritant to your stomach so please use antacid or PPI to reduce the risk of vomiting due to GERD or gastritis from vitamin C

 

[Nolongerlive]

Just thinking, is it possible that smoking lots of weeds/edible and taking lots of alcohol together can do the trick ?

 

[StoneCactus]

I'd highly recommend to use both pure amygdalin and vitamin C to maximize this interaction rather than using amygdalin from acorn kernels. Do note that vitamin C is irritant to your stomach so please use antacid or PPI to reduce the risk of vomiting due to GERD or gastritis from vitamin C

Which form of vitamin C would work better, extended release or regular? My understanding is that Vitamin C has a very short half life in the human body. There's also a study in guinea pigs that confirms that Vitamin C makes amygdalin work better here