Help Will Aripiprazole work as an antiemetic for the SN method?

[NTP_MAAR]

Hey guys, was wondering if Aripiprazole would work for the SN method? I don't have access to any of the other medications listed in the guide.

 

[andreamysk]

Its affinity value (Ki, inhibitory constant) to D2 receptors seems to be quite consistent (although I have found different values in different articles) so 'theoretically' it would seem so. These drugs however work well if they are ALREADY taken regularly, not as a one-off intake.

 

[NTP_MAAR]

Its affinity value (Ki, inhibitory constant) to D2 receptors seems to be quite consistent (although I have found different values in different articles) so 'theoretically' it would seem so. These drugs however work well if they are ALREADY taken regularly, not as a one-off intake.

How would you define regularly? Like a couple of weeks? Months?

 

[andreamysk]

Unfortunately I am neither a doctor nor a pharmacist; I just read in this thread https://sanctioned-suicide.net/thre...red-as-an-antiemetic-for-the-sn-method.38621/ the warning related to a drug belonging to the same category (although having a much lower affinity for the d2 receptor than Aripiprazole). Usually they are drugs that are taken by graduating the initial doses and then increasing until the desired effect is achieved. I wouldn't say months, a few days could be enough (consider the side effects carefully)

 

[tanaka10]

I don't think this is correct
Aripiprazole is a partial agonist of the dopamine D2 receptor, which greatly differentiates it from other antipsychotics which are antagonists of the dopamine D2 receptor, exactly like metoclopramide which is one of the best anti-emetics
aripiprazole, unlike other new generation antipsychotics, adapts to the dopaninergic environment so the anti-emetic effect varies with the agonist/antagonist action of aripripazol
it is better to take a complete antagonist

 

[NTP_MAAR]

I don't think this is correct
Aripiprazole is a partial agonist of the dopamine D2 receptor, which greatly differentiates it from other antipsychotics which are antagonists of the dopamine D2 receptor, exactly like metoclopramide which is one of the best anti-emetics
aripiprazole, unlike other new generation antipsychotics, adapts to the dopaninergic environment so the anti-emetic effect varies with the agonist/antagonist action of aripripazol
it is better to take a complete antagonist

Hmm. Would it be better to take Arip if you dont have access to anything else or not take it at all?

 

[tanaka10]

Hmm. Would it be better to take Arip if you dont have access to anything else or not take it at all?

I advise you instead to be prescribed metoclopramide. it is indicated for example in vomiting linked to migraine attacks. go to a doctor and tell them you have a migraine with shooting pain above your eye or temple and that you are vomiting. he should prescribe metoclopramide
Personally, I got it like this
aripiprazole is probably not very useful for combating vomiting

 

[like-spoiledmilk]

I advise you instead to be prescribed metoclopramide. it is indicated for example in vomiting linked to migraine attacks. go to a doctor and tell them you have a migraine with shooting pain above your eye or temple and that you are vomiting. he should prescribe metoclopramide
Personally, I got it like this
aripiprazole is probably not very useful for combating vomiting

I can 2nd this from experience.

Aripiprazole will not work. It has a very common side effect of *causing* nausea and vomiting, as well as a host of other GI issues. It's why patients taking antipsychotics need periodic metabolic panels completed.

Metoclopramide (or Reglan) is what you want.