Regarding vomitting with SN...

[KuRsAnI]

I only could acquire Meclizine as an antiemetic so I'm not sure if I'm going to vomit or not. I also have a body that's very prone to vomitting. I vomit such things as coca cola and coffee easily. Do you think mixing two doses of 20 gm/50 mL of SN should ensure that I ctb?

 

[beyond_aquila_rift]

Everyone is different from what I gather from this website. Yes antiemetics make for smoother intake and increase chance of success but even when some users ctb and take them, they vomit. We are all different :)

most people make two doses (I will do this too) because if you vomit you have that second dose to ensure absorption. Hope this helps. Hugs to you

 

[Quarky00]

One 25g serving should be enough even if some is vomited . This is the updated practice .

Old practice was to prepare two servings as you suggested . We have not heard of anyone using second serving , it was suggested hard to drink poison again when person just vomited , and it appears 25g is enough . However many will continue old practice .

Vomiting	SN fatal even if vomited 50ml on empty stomach (very little to vomit -- much remains)
PPH practice , vomiting	PPH Practice - 1 Big Serving Serving Size What happened Drank Vomited Absorbed #1 25g Vomited 25g 15g 10g Total SN 10g (fatal) If vomit within 10m – still fatal – no need for more SN

I only could acquire Meclizine as an antiemetic

Less effective than dopamine antagonists , but people have vomited with meto , and some without meto haven't vomited even when they tried . So it's very individual . According to few accounts it appears that people who are prone to vomiting on the first place are at a higher risk regardless ..

My heart goes out to you about that vomiting , I have similar things . It's awful I use meto (prescription ) daily to prevent vomiting .


More info is detailed here (Intake -> Vomiting):

https://sanctioned-suicide.net/threads/sn-faq-storage-recovery-death.29714/page-3#post-631049

 

[KuRsAnI]

Thanks for the dedicated answer quarky, but isn't it 20 grams per 50 mL of water for a regular sized body?

 

[autumnal]

I only could acquire Meclizine as an antiemetic so I'm not sure if I'm going to vomit or not. I also have a body that's very prone to vomitting. I vomit such things as coca cola and coffee easily. Do you think mixing two doses of 20 gm/50 mL of SN should ensure that I ctb?

If you are especially prone to vomiting, I would strongly recommend you obtain one of the recommended dopamine antagonist antiemetics rather than relying on meclizine alone. The causes of vomiting targeted by dopamine antagonists (i.e. toxins and chemicals in the stomach) and the types targeted by meclizine (i.e. motion sickness and vertigo) are different.

 

[esoragoto]

One 25g serving should be enough even if some is vomited . This is the updated practice .

Old practice was to prepare two servings as you suggested . We have not heard of anyone using second serving , it was suggested hard to drink poison again when person just vomited , and it appears 25g is enough . However many will continue old practice .

That extra 5g probably causes a notable increase in the probability of vomiting, though. If you're confident in your ability to not vomit and you're using antiemetics, you might be better off with 20g. Most people would rather avoid vomiting in their last minutes if they can help it.

 

[Quarky00]

That extra 5g probably causes a notable increase in the probability of vomiting, though

I wouldn't say that . Some vomited with 15g , some did not vomit with 25g . Significant increase will cause vomiting but I don't know if 5g is such . See PPH practice over the years (table)

If you're confident in your ability to not vomit and you're using antiemetics, you might be better off with 20g

Member is confident in their ability to vomit ..

isn't it 20 grams per 50 mL of water for a regular sized body?

As I mentioned there are two practices . It is detailed in the link . Please read .. :)

Dosage
PPH / Stan	To absorb more SN despite possible vomit -- two strategies emerged: PPH increased dose through the years: 15g –> 20g –> 25g Stan's multiple serving – if vomit take more, 3 x 20g Notes: How many actually drank several servings? Unconfirmed [1] Too much SN may cause instant vomiting? Unconfirmed*

* I think a members that over did it with 40-45g vomited and failed

 

[esoragoto]

I wouldn't say that . Some vomited with 15g , some did not vomit with 25g . Significant increase will cause vomiting but I don't know if 5g is such . See PPH practice over the years (table)

Yeah, tendency to vomit varies among individuals. But a 25% increase in dosage is pretty big - we'll probably never actually get good statistics about the relation between dose and tendency to vomit, but I'd be surprised if 25% didn't significantly increase your odds to vomit. PPH's increased dosage may have slightly better odds at killing you, but Stan's multiple servings could have better odds at giving you a peaceful death. A lot of people turn to SN for a peaceful death, and using PPH's pratice for everyone and increasing the odds of vomiting for people who may not need it is at odds with that goal. That being said, 25g may be better in this case.

 

[Quarky00]

Yeah, tendency to vomit varies among individuals. But a 25% increase in dosage is pretty big - we'll probably never actually get good statistics about the relation between dose and tendency to vomit, but I'd be surprised if 25% didn't significantly increase your odds to vomit. PPH's increased dosage may have slightly better odds at killing you, but Stan's multiple servings could have better odds at giving you a peaceful death. A lot of people turn to SN for a peaceful death, and using PPH's pratice for everyone and increasing the odds of vomiting for people who may not need it is at odds with that goal. That being said, 25g may be better in this case.

It's not linear .. The odds of peaceful / vomit do not seem to change in relation to dose:

Some vomited with 15g , some did not vomit with 25g

I'm not saying you're wrong or arguing We just don't have that info . I wouldn't make that conclusion because we did not see linear behaviour ("less is peaceful") and dosage was increased already significantly by PPH . As you say it seems common sense that increased dosage causes increase vomiting but things don't work that way, some people did not vomit even without AE , while other with AE vomited , and this shows us that each individual has particular response and specific threshold -- nothing general . Since we don't know the relation I wouldn't speculate .

 

[Emily123]

i am going to do it this Saturday .i don't have any doubt that i want to die . But i don't know how i can make myself mentally ready . i am still scared

 

[autumnal]

i am going to do it this Saturday .i don't have any doubt that i want to die . But i don't know how i can make myself mentally ready . i am still scared

You are probably going to get more responses either starting a new thread on this topic, or doing a search for existing threads on 'survival instinct'. Would recommend the second option be done first.

 

[KuRsAnI]

If you are especially prone to vomiting, I would strongly recommend you obtain one of the recommended dopamine antagonist antiemetics rather than relying on meclizine alone. The causes of vomiting targeted by dopamine antagonists (i.e. toxins and chemicals in the stomach) and the types targeted by meclizine (i.e. motion sickness and vertigo) are different.

Someone on this forum typed that meclizine is a dopamine blocker, and not used to treat motion sickness and vertigo. Damn them.

And I don't think I can find Reglan/Metoclopramide without a prescription in Canada... EDIT: I think I've found a site. EDIT2: Yeah I've found a website but it cost me a pretty penny lol

 

[autumnal]

Someone on this forum typed that meclizine is a dopamine blocker, and not used to treat motion sickness and vertigo. Damn them.

And I don't think I can find Reglan/Metoclopramide without a prescription in Canada... EDIT: I think I've found a site. EDIT2: Yeah I've found a website but it cost me a pretty penny lol

On further examination, meclizine is described as being 'also a dopamine antagonist at D1-like and D2-like receptors' in an uncited assertion on its Wikipedia entry.

However, it is not definitely not placed in the pharmacologic category of 'Dopamine antagonist' in its more trustworthy Drugs.com entry. On this reference (as well as on Wikipedia), it is also clearly listed as being for motion sickness and vertigo. So if a member has suggested otherwise on that aspect, they are definitely incorrect.

On the absence of any further clarification from someone with more expertise than me, I would therefore advise against relying on this medication as an effective antiemetic for the SN method. I will however pass this topic on to @Aap and/or @Quarky00 for their more experienced analysis.

 

[Aap]

The answer is most likely not. Like many older medications, these were developed and released when understanding of their pharmacology wasn't terribly well understood and were not specifically designed to target a certain receptor. This can result in having minor effects in many places.

Like many first generation antihistamines, this has moderate anticholinergic effects that likely account for most of the antiemetic activity. These are much more effective against motion induced vomiting and slow GI motility, which is unwanted effect with SN. Is it possible, it has D related effects? Possibly, but it isn't something that would be terribly productive for SN use.

 

[KuRsAnI]

Thanks for the answers, sirs. I will definitely discard my meclizine to replace it with the Reglan I've just purchased

 

[Quarky00]

meclizine is described as being 'also a dopamine antagonist at D1-like and D2-like receptors' in an uncited assertion on its Wikipedia entry.

Yeah it's flimsy . If it says "citation needed" so it's not reliable . Meclizine does not appear on the list of AE drugs receptor affinity. That D2 claim is dubious. As @Aap mentioned it affects motion not stomach chemoreceptor input -- affects sensory information from the ear (sensing motion/balance):

The drug depresses labyrinth excitability and vestibular stimulation

 

[autumnal]

[...] the list of AE drugs receptor affinity. [...]

Wow, just loaded that thing.

Let me guess, this is your personal equivalent of a porn magazine centrefold?

 

[Quarky00]

Let me guess, this is your personal equivalent of a porn magazine centrefold?

YES! Look at all those curvy sensual carbon rings... rrr aromatic

My van der Waals is hitting Avogadro.

(Apologies for sexuchemical content)

 

[KuRsAnI]

Should I be suspicious of where I get my Reglan since they don't ask for a prescription? Could this potentially be a scam?

 

[FluffyDove]

Should I be suspicious of where I get my Reglan since they don't ask for a prescription? Could this potentially be a scam?

What country are you from

 

[KuRsAnI]

What country are you from

Canada

 

[autumnal]

Should I be suspicious of where I get my Reglan since they don't ask for a prescription? Could this potentially be a scam?

I suppose it could theoretically be a scam. But it's probably more likely to be a genuine seller who is just slack with following the rules, regulations and laws. Which is what you need, ultimately.

 

[CAH]

If you are especially prone to vomiting, I would strongly recommend you obtain one of the recommended dopamine antagonist antiemetics rather than relying on meclizine alone. The causes of vomiting targeted by dopamine antagonists (i.e. toxins and chemicals in the stomach) and the types targeted by meclizine (i.e. motion sickness and vertigo) are different.

I am already taking Seroquel. Should I take extra, or is the 25 mg twice a day enough to already have my system in a non-vomiting state?

 

[autumnal]

I am already taking Seroquel. Should I take extra, or is the 25 mg twice a day enough to already have my system in a non-vomiting state?

See guide here:

• Guide to dosage of Quetiapine (Seroquel) required as an antiemetic for the SN method

 

[Giraffey]

Meclazine does bind to D1 and D2 receptors, but don't forget that there are dopamine receptors feeding from the vestibular system which regulate acetylcholine. The binding of meclazine to these vestibular receptors probably produces a synergistic effect (in addition to the primary mechanism of action on the histamine H1 receptors) in reducing ototoxicity (emetic input from the vestibular system - as in motion sickness), but it's of limited relevence to the dopamine and serotonin receptors fed by vagal afferents (emetic inputs from irritants in the stomach and intestines), or the CTZ.

That's a slightly over-complicated way of saying that Meclazines anti-emetic effect is of limited to no use with the SN method.

Although as a side note, if you're especially prone to vomiting and availability isn't a problem, a three drug anti-emetic combo might be the most effective - metoclopramide, ondanseron and Lorazepam. For most people that is serious overkill, and it's definitely not mandatory, but as I say if you have a very sensitive vomit reflex, can see vomiting being a big problem, and can obtain the meds - that might be the way to go.

Having said all of that, I know very little about SN as a drug so I'm going on general assumptions here. Also writing this when very tired so I apologize if there are any glaringly obvious errors

 

[Wisdom3_1-9]

Darn it. I just read about meclizine being a dopamine blocker so decided to check it out on SS to see if it had been discussed. I'm kinda glad but also not glad I came across this post. Glad to have the info, but sad that it won't work. Will stick with my original plan of not using an AE. *fingers crossed*

 

[user667]

Darn it. I just read about meclizine being a dopamine blocker so decided to check it out on SS to see if it had been discussed. I'm kinda glad but also not glad I came across this post. Glad to have the info, but sad that it won't work. Will stick with my original plan of not using an AE. *fingers crossed*

is not using an antiemetic at all better than using meclizine? cant hurt right? or does it make something worse?

 

[Wisdom3_1-9]

is not using an antiemetic at all better than using meclizine? cant hurt right? or does it make something worse?

Good question. I'm not sure I know the answer to that. In any case, I was able to get metoclopramide, so that alleviates that problem for me. I know it's not so easy for others, though.

 

[checkouttime]

If you look at the 3rd post down, Itshows how little SN is needed to CTB, even if vomiting occurs and a 2nd dose isn't ingested. But I would strongly advise having a 2nd dose available, if anything it will speed the process.

As you can see vomiting will not result in failure