Dosage accuracy becomes unreliable. SN is a fine powder, and even small mismeasurements can significantly affect outcome. Most lethality research and protocols rely on dissolving 25g of SN in 50 mL of water, which ensures uniform absorption and immediate bioavailability. Capsules make it harder to track the exact dose ingested. Capsules (especially gelatin or veggie based) take time to dissolve in the stomach, which can delay SN absorption. This delay may increase the risk of vomiting, survival, or SI interference — all things the protocol is specifically designed to reduce. If vomiting occurs before the capsules fully dissolve, a portion of the SN may not be absorbed at all, resulting in failed or incomplete attempts. While some people explore capsules to avoid the salty, unpleasant taste of SN solution, this comes at the cost of reduced reliability. A better alternative is to cool the solution beforehand or suck on a mint afterward rather than bypass the standard method.
For maximum efficacy and according to the PPH and broader community consensus, SN should be measured, dissolved in water, and ingested on an empty stomach after antiemetic preparation. Capsules introduce uncertainty and risk and for a method that depends so heavily on precision, that risk may not be worth taking.