Help Propranolol extended release and SN

[HopelessFight]

I would like to use Propranolol when taking SN to pass out faster and reduce heart beat when I CTB.

I have managed to get Propranolol. Hoever, the only one I could get access to are the 80mg Extended Release tablets instead of the IR tablets.

How would you best approach this when combining with SN?

 

[rvsw]

I also need to know

 

[0siris]

I also need to know

A: Extended release

B: Immediate release

As you see the peak for IR is at about 30min and then it declines quickly.

The peak for ER is at about 1 hour and then declines slowly.

Note that the IR tablets have a peak at about 350ng/L, while the ER tablets have peak at about 180ng/L, so basically x2.

So if you take one 80mg tablet of an IR, you'd need to take 160mg of an ER to get the same peak concentration after 1 hour.

Mean propranolol plasma concentrations versus time profiles of...

Download scientific diagram | Mean propranolol plasma concentrations versus time profiles of formulation (A) extended-release tablets of ER-F (▴) and ER-S (■); (B) immediate-release commercial products (IR) (♦). from publication: Development and validation of an in vitro–in vivo correlation...

www.researchgate.net

(This is just the maths, pls check for side effects yourself)

 

[Jumper Geo]

If you crush them first and dissolve them in water and then add the SN they are no longer slow release but if your worried just leave them in a glass of water in the fridge and when your ready add the SN actually might be a good idea to use chilled water, lol, it might make it more bearable.

Cheers

Geo