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wheelsonthebus

wheelsonthebus

vroom vroom
Apr 1, 2022
35
OD is not regarded as a reliable method, with shockingly low success rates, although that is attributable in part to overdoses on substances like benadryl and ibuprofen also counting, if my understanding is correct.

My original method of choice was going to be a polysubstance overdose that included items that alone would not even be worth considering as methods, but taken together with other pills and potentially booze was to (hopefully) result in sedation and grand mal seizures until death. It was inspired from an experience I had waking up from general anesthesia for surgery: I was aware of where I was and what had happened, as well as who was in the room and what was expected of me. However, I did not care. About anything! Including breathing. I consciously decided to take advantage of not feeling any need to breath to see how it would feel, and realized, hey, feels pretty great to not freak out at holding your breath too long! The nurse, however, disagreed.

That said, I am beginning to doubt my own pharmacological understanding. Here was the original medicine cabinet, though I'm sure taking all of the pills would have been an immediate vomiting situation and overkill:

Pills:
- oxycodone 5 mg (5 count).
- tramadol 50 mg (9 count)
- tramadol-acetaminophen 37.5-325 (15 count)
- propranolol 10 mg (25 count)
- quetiapine fumarate 50 mg (60 count)
- escitalopram 10 mg (25 count)
- bupropion HCL XL 150 mg (6 count)*
Capsules:
- gabapentin 300 mg (20 count)
- hydroxyzine pamoate 50 mg (15 count)
- venlafaxine XR 37.5 mg (15 count), 70 mg (10 count) (XR capsule can be removed and beads crushed)
Additional:
- Alcohol, sipped to avoid gagging (I struggle with shots) 3 drinks worth.
- Grapefruit juice
Suspected outcome:
3-5 on Glasgow coma scale and low respiratory rate from quetiapine, opiods, and propranolol, as well as severe hypoxia
Bradycardia or ventricular tachy from the seratonin toxicity
Severe hypotension from cardiogenic shock (propranolol and quetiapine)
Prolonged QT interval so a high risk of fatal arrhythmia
5-10% survival without immediate care, no awareness of death due to rapid CNS depression, becoming drowsy and out of it within 30-60 minutes, fully unconscious within 1 or 2 hours. In other words, sedation would prevent experiencing air hunger.
Grand mals until brain is soup? vvv
*I feel that removing bupropion wouldn't raise survival odds too badly but would make it less likely to vomit everything up before passing out. However, this was the biggest contributor to the tonic clonic/grand mal seizure outcome.
I suspect a strong AE would be required, because surely the body would vomit?
I have lots of sublingual odansetron, hyoscyamine 0.125 sublingual, and promethazine.

Would back to back tonic-clonic seizures be realistic? You'd be unconcious, but would it be lethal? I worry it's not reliable.

Interestingly, with EMT response and a quick drive to the ER within an hour or so, assuming they approached treatment correctly, within a few days you would be fine. No permanent damage, I don't believe, But it would require ventilation, total irrigation of the digestive system, the works. So ideally this is done far away from other people.
 
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spero_meliora

spero_meliora

In hope for better things.
Jan 13, 2025
228
not reliable enough. this combo is most likely to end in a really deep sleep or possibly seizures, you're going over the 400mg threshold of tramadol and combining it with antidepressants is also going to increase that risk, and you're going to put yourself at risk for serotonin syndrome.

don't do this. you may end up causing yourself harm but will likely still live, and if you're conscious it'll be extremely uncomfortable.


edited to add:
 
Last edited:
NearlyIrrelevantCake

NearlyIrrelevantCake

The Cake Is A Lie
Aug 12, 2021
2,251

 
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wheelsonthebus

wheelsonthebus

vroom vroom
Apr 1, 2022
35
not reliable enough. this combo is most likely to end in a really deep sleep or possibly seizures, you're going over the 400mg threshold of tramadol and combining it with antidepressants is also going to increase that risk, and you're going to put yourself at risk for serotonin syndrome.

don't do this. you may end up causing yourself harm but will likely still live, and if you're conscious it'll be extremely uncomfortable.


edited to add:

OK, word, I thought this might be the case, thank y'all. I feel like the only reliable overdose methods require F or similar, and after the archetyp takedown that's hardly available
 
RunDown

RunDown

Getting ready to go
Jun 18, 2025
37
It's not reliable enough. Psych med damage is a real concern. I'm a victim of serotonin syndrome caused by effexor and it has ruined my life. I have terrible neurological symptoms that have brought me here. Don't do it. You don't want to end up in the hell I'm currently in.
 
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madameviolette

madameviolette

Made sick by medical institutions
Oct 9, 2025
149
The reason I'm here is because of meds damage. I'm in constant hypoxia and have seizures. I feel like I'm drowning day and night and I claw at my bed and body because I can't breath. My nerves have been damaged from depressants (that I used as prescribed).
All my limbs are tingling and burning, no more blood circulation and it feels like I'm burnt into acid. I also have hallucinations from the lack of oxygen.

You could try your method, it might work. But if it doesn't work you should consider the risk of living with after side effects like hypoxia and brain damage that feels like suffocation
 

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