Help Morphine with no effects?

[CynicalCyanide]

Hey,

I was testing the morphine I aquired by taking a dosage that should make you high. I didn't experience any high at all, maybe slightly a higher pressure in my neck/head.
I took 50mg and I have no tolerance. But the thing is, it were extended release pills of 200mg. So I crushed the pill and took 1/4th of the amount, expecting this would make it instant release.
On the web I see warnings to not crush or chew the pill for risks of overdose bc of the extended release coat not working anymore. But I wanted to ask you people: is it still possible that it was slow released even though I crushed it, in combination with the small amount, that made it have no to little effect? I can't find it specifically on the web :/

Fyi, I swallowed it with water on an empty stomach.

 

[whywere]

I am and have been on Hydromorphone for almost 10 years now for 24/7 chronic pain from a VERY nasty car crash. Car crash NOT my fault whatsoever, just wrong place at the wrong time.

If swallowing an opioid, remember that a human has opioid receptors in the gastrointestinal tract beside in the brain.

Not only does a person's DNA have an outcome on how opioids work or do not work for a person, BUT everything from gene mutation to a significant effect of personality and psychology, a human can lean towards suffering than overcoming an issue(s) and the source of the pain all contributes to how or how they do not work in a human.

From everything that I know, being taught by my pain clinic team, opioids work entirely different in almost each and every person. It may be in one's face, or it can be very subtle.

My medical team is an awe that I have been on Hydromorphone for this long at the same dosage and it still work fine for me.

Walter

 

[lionetta12]

Hey,

I was testing the morphine I aquired by taking a dosage that should make you high. I didn't experience any high at all, maybe slightly a higher pressure in my neck/head.
I took 50mg and I have no tolerance. But the thing is, it were extended release pills of 200mg. So I crushed the pill and took 1/4th of the amount, expecting this would make it instant release.
On the web I see warnings to not crush or chew the pill for risks of overdose bc of the extended release coat not working anymore. But I wanted to ask you people: is it still possible that it was slow released even though I crushed it, in combination with the small amount, that made it have no to little effect? I can't find it specifically on the web :/

Fyi, I swallowed it with water on an empty stomach.

Get a bloodtest to get your CYP checked for mutations. I have it and opioids have no effect on me really due to my genes.

 

[CynicalCyanide]

Get a bloodtest to get your CYP checked for mutations. I have it and opioids have no effect on me really due to my genes.

Omg, I'm researching it now. If this is in my case I feel oretty fucked since it was a key part of my plan.
I can't really find it that quick, but maybe you know: does this mean all opioids don't work? Even heroine? Is this only if you ingest it or does it mean IV won't work as well?
And how did you figure it out? I dont think they won't test me randomly for it just because I said so. And I wont explain why since I didn't get it prescribed.

 

[lionetta12]

Omg, I'm researching it now. If this is in my case I feel oretty fucked since it was a key part of my plan.
I can't really find it that quick, but maybe you know: does this mean all opioids don't work? Even heroine? Is this only if you ingest it or does it mean IV won't work as well?
And how did you figure it out? I dont think they won't test me randomly for it just because I said so. And I wont explain why since I didn't get it prescribed.

It depends which CYP mutation you have or don't have. I have a no/low metabolism CYP mutation when it comes to opioids, SSRI's and a certain heart mediciation as well apparently (this also helped explain why antidepressants didn't work on me either) which means my body cannot physically metabolize opioids and these other medications. I've had tramadol, codein, oxycontin, oxynorm, surgical fent while being under full anesthesia and paralgin forte after an ankle surgery which had no effects. They'd give it to me at the hospital before the surgery and I'd try to explain that I was in pain still and I felt no different. I've never experienced a "opioid high" either. My mom somehow feel that from tramadol and gets pain relief on it. After having had opioids offered to me for a year and a half after the surgery and after explaining over and over that it doesn't work and it never worked, I did tell my doctor that I have a grandfather who also has this thing with opioids as well who had recently survived cancer. I asked if maybe I had the same thing and she agreed to give me a bloodtest for this and it confirmed that I can't metabolize it. I think my grandfather is a low metabolizer of the opioids so he had to be given some large dosages of opioids to feel any pain relief when he went through his chemotherapy. I will say that they did eventually give me ketamine for the ankle a couple times after they realized that the opioids didn't work, I did feel pain relief from that, but I never felt "high" or "better mentally" for the brief 5-10 minutes that they injected me with ketamine through IV's. I've never woken up from a surgery foggy or "high", and it seems to freak out every nurse that I've ever spoken to after every surgery I've had because they usually say that they haven't experienced this before. I feel the pain, but there's nothing I can do about that. I just get up and start walking around and say I'm ready to leave and start reading my medical journal until they let me go home usually. That's how I found out that they have tried to give me fent during my recent surgery a couple months ago after I explained the opioid CYP mutation that I have before the surgery happened. Woke up with some freaky looking pupils, but other than that, did not feel or notice a difference.

 

[whywere]

Get a bloodtest to get your CYP checked for mutations. I have it and opioids have no effect on me really due to my genes.

VERY interesting!

So many times, medical folks have told me "Look at your past generations and you will see"

Thank you so much for the info!

Walter

 

[CynicalCyanide]

It depends which CYP mutation you have or don't have. I have a no/low metabolism CYP mutation when it comes to opioids, SSRI's and a certain heart mediciation as well apparently (this also helped explain why antidepressants didn't work on me either) which means my body cannot physically metabolize opioids and these other medications. I've had tramadol, codein, oxycontin, oxynorm, surgical fent while being under full anesthesia and paralgin forte after an ankle surgery which had no effects. They'd give it to me at the hospital before the surgery and I'd try to explain that I was in pain still and I felt no different. I've never experienced a "opioid high" either. My mom somehow feel that from tramadol and gets pain relief on it. After having had opioids offered to me for a year and a half after the surgery and after explaining over and over that it doesn't work and it never worked, I did tell my doctor that I have a grandfather who also has this thing with opioids as well who had recently survived cancer. I asked if maybe I had the same thing and she agreed to give me a bloodtest for this and it confirmed that I can't metabolize it. I think my grandfather is a low metabolizer of the opioids so he had to be given some large dosages of opioids to feel any pain relief when he went through his chemotherapy. I will say that they did eventually give me ketamine for the ankle a couple times after they realized that the opioids didn't work, I did feel pain relief from that, but I never felt "high" or "better mentally" for the brief 5-10 minutes that they injected me with ketamine through IV's. I've never woken up from a surgery foggy or "high", and it seems to freak out every nurse that I've ever spoken to after every surgery I've had because they usually say that they haven't experienced this before. I feel the pain, but there's nothing I can do about that. I just get up and start walking around and say I'm ready to leave and start reading my medical journal until they let me go home usually. That's how I found out that they have tried to give me fent during my recent surgery a couple months ago after I explained the opioid CYP mutation that I have before the surgery happened. Woke up with some freaky looking pupils, but other than that, did not feel or notice a difference.

So interesting and informative, thank you. And if i understand correctly, the there is no difference whether you take it orally or IV? Or do you think through IV it still has effect since your body won't have to/differently has to metabolize it?

 

[lionetta12]

So interesting and informative, thank you. And if i understand correctly, the there is no difference whether you take it orally or IV? Or do you think through IV it still has effect since your body won't have to/differently has to metabolize it?

I'm not sure, I've only had it through IV when I was under full general anesthesia under surgery and that was fent. I felt pain when I woke up and felt like myself, just weird looking pupils which I have not noticed before when I had taken various opioids in pill form.