Metoclopramide, Prochleperazine or Domperidone for sn?

[Hope:-)]

Hi. I'm going to the doctor tomorrow and I don't know which to ask for. I'm UK based in case all these medications aren't available over here. I take an antipsychotic which I have read mixed with meto can increase the chances of a movement disorder. Which is the best antiemetic as I really don't want to vomit as I have swallowing issues already which already increases my chances of asphyxiation Any feedback very much appreciated Thanks..

 

[Hope:-)]

Thanks for your response. How come you're also using ordansetron?

 

[Jrmull1993]

@Hope:-)

Without knowing what medications you are currently taking its hard to give a particular reccomendation. In your case, it might be best to ask for an antiemetic, but not specify a particular type and leave it to your physician to determine what is best based on the medications you are taking.

Metoclopramide: You stated that there is a possible adverse reaction that can occur with another medication you are currently taking. Perhaps mentioning this medication to your doctor. He/she will be able to tell you the chance of the side affect, or be able to reccomend a biosimilar drug.

Prochleperazine: You state that you are currently on an antipsychotic drug. Being that prochleperazine has many antipsychotic traits, there is a very high chance of this drug having an adverse effect.

Domperidone: This medication is very different than most other antiemetics. Doperidone works by triggering contractions in the stomach and intestinal track. It is typically reserved for use in tandem with other drugs which can trigger stomach irritation. Antiemetics such as metoclopramide, work by inhibiting signals from the brain which trigger the nerves controlling muscles that are used in the regurgitating process. Here is a link to a recent megathread post on this drug, explaining it in more detail.

 

[Hope:-)]

@Hope:-)

Without knowing what medications you are currently taking its hard to give a particular reccomendation. In your case, it might be best to ask for a antiemetic, but not specify a particular type and leave it to your physician to determine what is best based on the medications you are taking.

Metoclopramide: You stated that there is a possible adverse reaction that can occur with another medication you are currently taking. Perhaps mentioning this medication to your doctor. He/she will be able to tell you the chance of the side affect, or be able to reccomend a biosimilar drug.

Prochleperazine: You state that you are currently on an antipsychotic drug. Being that prochleperazine has many antipsychotic traits, there is a very high chance of this drug having an adverse effect.

Domperidone: This medication is very different than most other antiemetics. Doperidone works by triggering contractions in the stomach and intestinal track. It is typically reserved for use in tandem with other drugs which can trigger stomach irritation. Antiemetics such as metoclopramide, work by inhibiting signals from the brain which trigger the nerves controlling muscles that are used in the regurgitating process. Here is a link to a recent megathread post on this drug, explaining it in more detail.

Thanks for your help. Why is domperidone generally used in tandem with other drugs? Can you not use it on it's own as an antiemetic? I'll read the thread. Looking to go soon so I'm getting impatient.

 

[Jrmull1993]

Thanks for your help. Why is domperidone generally used in tandem with other drugs? Can you not use it on it's own as an antiemetic? I'll read the thread. Looking to go soon so I'm getting impatient.

I dont have any facts to back this up, but my assumption is because the contractions caused by domperidone help prevent medications from "settling" in the stomach. Some medications are prone to causing stomach irritation, which is when domperidone is normally given in tandem.

Many "dopamine precursor" drugs are first line treatments for Parkinsons and Arthritis patients. They are rapidly absorbed into the bloodstream but the agents to bind them remain in the stomach, and are known irritants.

If you speak with your doctor and request something to reduce the frequency of vomiting and nausea, they'll know what is best for you, and will be most compatible with the medications you are presently taking.