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Help Metoclopramide interaction with antidepressant

D

dogemn

I can't go on. I'll go on.
May 30, 2023
158
I'm on 300mg of wellbutrin (bupropion) daily, and when I took 30mg of metoclopramide on an empty stomach I started experiencing severe akathisia. Do I have to stop my antidepressant in order to take metoclopramide with SN?
 
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T

Thalassa

Member
Jul 24, 2018
56
Did you stop the akathisia by taking Benadryl? I would avoid meto if I were you. But I'm not saying to not take an antiemetic.
 
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D

dogemn

I can't go on. I'll go on.
May 30, 2023
158
Thalassa said:
Did you stop the akathisia by taking Benadryl? I would avoid meto if I were you. But I'm not saying to not take an antiemetic.
Click to expand...
No, I couldn't stop it but I was able to put up with it after taking propranolol and alprazolam. Why should I avoid meto? What other antiemetic could I take?
 
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T

Thalassa

Member
Jul 24, 2018
56
You should research extrapyramidal symptoms (EPS) and metoclopramide. In rare cases a person can get EPS from a single dose of meto. Akathisia is an extrapyramidal symptom.
 
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D

dogemn

I can't go on. I'll go on.
May 30, 2023
158
Thalassa said:
You should research extrapyramidal symptoms (EPS) and metoclopramide. In rare cases a person can get EPS from a single dose of meto. Akathisia is an extrapyramidal symptom.
Click to expand...
I know, I did experience that side effect after taking 30mg while I was on 300mg daily bupropion.
 
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caramelpudding

caramelpudding

unlucky me
May 20, 2026
84
I wonder if you prepared everything before hand like pre-mixing SN will you be able to push through akathisia and drink the solution?
 
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