Method Is higher dose better?

[sawsy]

I am learning it seems the most important thing is to mix substances but is it necessary more affective if you were to take like thousands of mg of each of those substances or would that just make you sick

 

[Forveleth]

This highly depends on the "substance" you are talking about. I am guessing you are asking about prescription pills. Most of the time it does not matter how much you take as you are more likely to survive. There are also problems with "just taking more".
1. Physical limitations. Sometimes you can not physically get in enough pills before there are side effects or your stomach is full.
2. Increased side effects, including vomiting. In large amounts, drugs are poison to your body and it will naturally try to expel them by vomiting. You can take 100 pills but you might end up puking out 90 of them.