greyhound
Arcanist
- Oct 8, 2020
- 471
Came across this interesting quote:
In 2018, a gas chromatography–mass spectrometry study quantified agmatine levels in the brains of post-mortem humans who died by suicide and showed reduced agmatine levels in the suicide cortex regardless of these individuals formerly meeting the criteria for MDD versus controls[56].
pubmed.ncbi.nlm.nih.gov
I was reading this article which summarizes the findings of agmatine as an anti depressant:
Valverde AP, Camargo A, Rodrigues ALS. Agmatine as a novel candidate for rapid-onset antidepressant response. World J Psychiatr 2021; 11(11): 981-996 [PMID: 34888168 DOI: 10.5498/wjp.v11.i11.981]
I started taking agmatine a few days ago to try to repair some of my receptors post-opiate usage as I had read it can reduce opiate tolerance. I have been feeling really positive though all of a sudden and wondered what could be responsible. Seems agamatine is fairly unknown but could be pretty effective at countering depression. It works on receptors similar to Ketamine which is starting to be used for depression clinically.
In 2018, a gas chromatography–mass spectrometry study quantified agmatine levels in the brains of post-mortem humans who died by suicide and showed reduced agmatine levels in the suicide cortex regardless of these individuals formerly meeting the criteria for MDD versus controls[56].
Evidence of Reduced Agmatine Concentrations in the Cerebral Cortex of Suicides - PubMed
This is the first gas chromatography-mass spectrometry study to analyze agmatine concentrations in human postmortem brain of individuals who died by suicide. These results add to our mechanistic understanding of the role that the polyamine stress response pathway may play in the neurobiology of...
pubmed.ncbi.nlm.nih.gov
I was reading this article which summarizes the findings of agmatine as an anti depressant:
Valverde AP, Camargo A, Rodrigues ALS. Agmatine as a novel candidate for rapid-onset antidepressant response. World J Psychiatr 2021; 11(11): 981-996 [PMID: 34888168 DOI: 10.5498/wjp.v11.i11.981]
Agmatine as a novel candidate for rapid-onset antidepressant response
Agmatine as a novel candidate for rapid-onset antidepressant response
www.wjgnet.com
I started taking agmatine a few days ago to try to repair some of my receptors post-opiate usage as I had read it can reduce opiate tolerance. I have been feeling really positive though all of a sudden and wondered what could be responsible. Seems agamatine is fairly unknown but could be pretty effective at countering depression. It works on receptors similar to Ketamine which is starting to be used for depression clinically.
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