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FrozenOcean

FrozenOcean

…oh bother
Mar 21, 2025
75
It seems like the use of antacids for the SN protocol are still controversial. Some say it will speed up the conversion of NO in the small intestine and others say it will slow it down, the theory is that speeding it up could result in a quicker death. I'm not sure what to think, but it would seem to me that if in doubt, throw it out. Otherwise you're complicating the process and taking a risk that isn't necessary. What does everyone else think?
 
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Unspoken7612

Arcanist
Jul 14, 2024
469
Some say it will speed up the conversion of NO in the small intestine and others say it will slow it down, the theory is that speeding it up could result in a quicker death.
This is entirely wrong.

It is the nitrite that causes death (by oxidising haemoglobin to methaemoglobin), not nitrous oxide. Nitrous oxide is an unwanted byproduct caused by the reaction of nitrite with stomach acid.

In theory, an antacid should reduce the rate of reaction between stomach acid and nitrite, meaning more nitrite makes it to the small intestine and is then absorbed into the bloodstream. In practice, however, it seems that this impact is minimal.

An antacid is not recommended by the Peaceful Pill Handbook. It won't do any harm except potentially making it slightly more likely you vomit (although there isn't evidence to support that). It is also unlikely to do much good except relieving some of the discomfort caused by nitrous oxide.
 
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Forveleth

I knew I forgot to do something when I was 15...
Mar 26, 2024
2,315
I tend to follow what the PPH says because they have gathered data on this, so they would know. I believe their stance is that they do not see any particular advantage to using an antacid, so they do not recommend it. Why take something extra that is not actually going to help you?
 
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FrozenOcean

FrozenOcean

…oh bother
Mar 21, 2025
75
This is entirely wrong.

It is the nitrite that causes death (by oxidising haemoglobin to methaemoglobin), not nitrous oxide. Nitrous oxide is an unwanted byproduct caused by the reaction of nitrite with stomach acid.

In theory, an antacid should reduce the rate of reaction between stomach acid and nitrite, meaning more nitrite makes it to the small intestine and is then absorbed into the bloodstream. In practice, however, it seems that this impact is minimal.

An antacid is not recommended by the Peaceful Pill Handbook. It won't do any harm except potentially making it slightly more likely you vomit (although there isn't evidence to support that). It is also unlikely to do much good except relieving some of the discomfort caused by nitrous oxide.
Thanks for clarifying!
 

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