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n enema
Thread starterZzzzz
Start date
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If someone has an N enema, and uses a plug, and they are in a coma( which is supposed to happen) will the N leak out while they are in a coma with a plug? Is it possible that the plug will fall out during a coma?
The fact that Tokyojoe went into detail about his method, hasn't logged in since his CTB date, made a goodbye thread, AND was confirmed by his staff through another user to have CTB is proof enough for me and many other users.
She told me she knew him IRL in a DM. The fact that Tokyojoe went into detail about his method, hasn't logged in since his CTB date, made a goodbye thread, AND was confirmed by his staff to have CTB is proof enough for me and many other users.
If that's good enough for you to take on balance of probability, so be it. It's still unconfirmed. Fwiw goodbye threads on here count for literally zero, and "confirmed by his staff" means absolutely nothing in relation to us here, but if people want to shove their N up their arse in good faith then l guess I'm pleased for them.
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Smashingairwaves, Zzzzz, Lifeisatrap and 1 other person
If that's good enough for you to take on balance of probability, so be it. It's still unconfirmed. Fwiw goodbye threads on here count for literally zero, and "confirmed by his staff" means absolutely nothing in relation to us here, but if people want to shove their N up their arse in good faith then l guess I'm pleased for them.
Just reread your choice of words, my friend. You can easily state your pov without being crass and disrespectful. So why do it just for shits and giggles?
Just reread your choice of words, my friend. You can easily state your pov without being crass and disrespectful. So why do it just for shits and giggles?
"Shits and giggles" where? The point I'm making here is that the same example crops up as evidence of a successful and peaceful ctb with a method which is relatively untried and it's potentially costly, financially or otherwise, for someone to stick 200ml of vet N in their anus based on the literally unconfirmed hearsay of a successful passing with 100ml of dolethal. If people choose to put faith in that evidence then fair enough, but it's not disrespectful to make folk aware that that evidence is far from concrete.
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SeekingSolace, Lifeisatrap, Johnnythefox and 1 other person
"Drugs administered PR have a faster action than via the oral route and a higher bio-availability – that is, the amount of effective drug that is available is greater as it has not been influenced by upper gastrointestinal tract digestive processes. Rectal absorption results in more of the drug reaching the systemic circulation with less alteration on route. As well as being a more effective route for delivering medication, rectal administration also reduces side-effects of some drugs, such as gastric irritation, nausea and vomiting (Tortora and Derrickson, 2008)."
Source: https://www.nursingtimes.net/clinic...ration-in-adults-how-when-why/7002595.article
It is likely reliable.
And Tokyojoe has not returned to inform other users of this method failing - in addition to alleged confirmation.
Anybody have a Ouija board?
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Kokobushi_bae26, Smashingairwaves, oneofthesedays and 6 others
If someone has an N enema, and uses a plug, and they are in a coma( which is supposed to happen) will the N leak out while they are in a coma with a plug? Is it possible that the plug will fall out during a coma?
Type anal / rectal plug into google and they'll be available to buy. Just don't buy a second-hand one, even if they are considerably cheaper.
There is literally no evidence of the success of an N enema anyway, obviously the choice is up to the individual but as I've stated elsewhere this is probably very likely to lead to a very expensive failure.
Reactions:
killing me softly, Smashingairwaves, Lifeisatrap and 3 others
Type anal / rectal plug into google and they'll be available to buy. Just don't buy a second-hand one, even if they are considerably cheaper.
There is literally no evidence of the success of an N enema anyway, obviously the choice is up to the individual but as I've stated elsewhere this is probably very likely to lead to a very expensive failure.
there are tons of questions on SS about rectal administration of drugs.
i would be very wary of rectal admin of anything unless you have found a medical resource showing it's efficacy.
the fact is there are a lot of factors that are important to consider:
- some drugs have been shown to absorb slower than oral admin, some faster. the rate of absorption for most drugs is not known.
- volume of the drug is going to impact the delivery route too. a small suppository or small amount of liquid will indeed enter the bloodstream directly (and bypass the liver) but a larger amount will enter a upper area of the rectum or colon and will enter the liver and be subject to it's metabolism
Drug Absorption by Sublingual and Rectal Routes
A. G. De Boer, L. G. J. De Leede And D. D. Breimer
The disadvantages associated with administration of drugs rectally include:
(a) interruption of absorption by defaccation, which may occur particularly with irritant drugs;
(b) the surface area of the rectum is far smaller for absorption than that of the duodenum;
(c) the fluid contents of the rectum are much smaller than those of the duodenum and this may produce problems with dissolution of some drugs;
(d) degradation of some drugs by micro-organisms may occur in the rectum;
Exploring the Unconventional Routes — Rectal and Vaginal Dosage Formulations
The Pharmaceutical Journal (A Royal Pharmaceutical Society publication):
"However, drug delivery via the rectal cavity can be challenged by erratic drug absorption due to potential expulsion of the dosage form and low adhesion to the rectal membrane. In addition, drug bioavailability is affected by the site of drug absorption within the rectal cavity. The superior rectal veins go via the liver whereas the inferior rectal veins bypass liver metabolism, thus correct positioning of the dosage form, at the lower rectum, is crucial."
if you are considering this with your method please research it carefully.
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