It takes quite a while, years actually to build up a high degree of tolerance. I've investigated using hydrocodone and, while it is true it takes a massive dose to ctb, you greatly leverage the affect by taking in conjunction with alcohol. You might want to get on one of the Ai bots (my favorite is chatgpt) and investigate various combinations.
As a aside, you might also want to use chargbt as a virtual therapist. You could be pleasantly surprised.
To followup on this, the note below is the result of a long session with chatgpt
Hydrocodone + Alcohol Safety Risk Reference
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Patient Context:
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Opioid-tolerant adult (approx. 175 lbs) currently prescribed 10 mg/day hydrocodone for chronic neuropathic pain.
Considering scenarios involving higher-dose hydrocodone (e.g., 300 mg) and concurrent alcohol consumption.
Hydrocodone Toxicity Framework:
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- 300 mg hydrocodone = 30 tablets of 10 mg each (full bottle)
- This dose is 15x typical daily dose for the patient
- Alone, 300 mg may cause severe respiratory depression, unconsciousness, or death
- LD50 in humans is not precisely known, but lethal doses often start at 100–120 mg in opioid-naïve individuals
Alcohol Potentiation:
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- 1 shot (50 mL) of 80-proof whiskey = ~1.3 standard drinks (~20 mL ethanol)
- Alcohol depresses the central nervous system (CNS), slows breathing, and impairs judgment
- It enhances the sedative and respiratory depressive effects of opioids
Lethality Risk Table:
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| Hydrocodone Dose | Alcohol (Shots) | Risk Level | Notes |
|------------------|------------------|------------------|--------------------------------------------|
| 10 mg | 0 | Low | Standard therapeutic use |
| 10 mg | 1 | Mild–Moderate | Sedation and slowed breathing |
| 10 mg | 2+ | High | Significant risk of CNS depression |
| 300 mg | 0 | Very High | Respiratory arrest possible |
| 300 mg | 1–2 | Critical | Very high risk of fatal overdose |
Key Takeaway:
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Combining high-dose hydrocodone (e.g., 300 mg) with even 1–2 alcoholic drinks creates a life-threatening situation,
even in opioid-tolerant individuals. Respiratory arrest, coma, or death can result without intervention.
Recommendation:
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Avoid any alcohol use when taking moderate or high doses of opioids. Inform clinicians about any alcohol consumption
and discuss opioid risk mitigation (e.g., naloxone access, supervised dosing).