Hello:
I put up a number of posts around meds and overdoses and chemicals. Although prescription and OTC meds can indeed be fatal, they have a very high rate of survival. Local effects in your body, GI, metabolism and many other factors can contribute to these chemicals being non lethal. Although the drugs you are describing have much more potency and mechanisms of action than common OTC medicines, they are not specifically lethal and therefore even in combination will give no guarantee of catching the bus. Cocktails of drugs and alcohol can be lethal and we see that in celebrity hotel binge stories but we also see dozens of overdose stories per weekend where people are hauled convulsing into an ER with survival but some sort of organ or other damage.
I highly advise against attempting to catch the bus with any OTC, alcohol or medical combination. The most likely effect will be nausea and vomiting with potential for other damage and a slim chance of death.