Enteric capsules and SN

[Peter Skellern]

Enteric capsules also known as extended-release or Gastro-resistant capsules, are uniquely designed to resist the acidic environment of the human stomach during the digestive process until they reach the next step of digestion.

They are treated with a material to prevent or minimize dissolution in the stomach, allowing it only in the small intestine. This type of formulation either shields the stomach from a potentially irritating drug or shields the drug from partial degradation in the acidic environment of the stomach bypassing the stomach and delivering its content to the intestines.

In other words, this means that they pass through the stomach intact, and then dissolve approximately one to two hours after ingestion when they reach the alkaline environment of the small intestine.

Simply put these capsules can potentially be used to deliver SN to the body without the risk of stomach discomfort or vomiting making it a far more peaceful experience for those looking to explore suchlike.

It's estimated 18 '00' Enteric capsules would be necessary for the 25 grams. These are readily available online. As is cheap capsule capping equipment if a person wants a professionally approach.

 

[be or not to be]

I think the people who took it here used regular capsules. I see a lot of risk because you wouldn't flood the system. It could be lethal, possibly but there's no data.

 

[Peter Skellern]

I think the people who took it here used regular capsules. I see a lot of risk because you wouldn't flood the system. It could be lethal, possibly but there's no data.

The SN is entering your body (swallowing) at the same time. The capsules will release their contents at approximately the same time. And of course it doesn't take 25 grams to be successful. A far, FAR lesser amount will suffice. There's been three examples already on here.

 

[be or not to be]

I know that a lower dose can be fatal but we don't know how it will affect them, if they are released at the same time, they stick together in the intestine. We don't have a timeline like there is with the drink.

 

[Peter Skellern]

I know that a lower dose can be fatal but we don't know how it will affect them, if they are released at the same time, they stick together in the intestine. We don't have a timeline like there is with the drink.

I would imagine they'll be absorbed via the intestines exactly as other medication is ingested via that method. Taking medication via Enteric Capsules is hardly a new approach. The science of it is well established.

"The time required for an enteric-coated dosage form to reach the intestine mostly depends on the presence and type of food in the stomach. It varies from 30 minutes up to 7 hours, with an average time of 6 hours." I would think with an empty stomach it will be at the quicker end.

 

[ChefTesta]

My question is, would anitemetics still be needed? I already used up all my legit ones unfortunately, so do you guys think OTC ones like Dramamine, Pepto-Bizmol and Emetrol would be sufficient?

 

[Forever Sleep]

I have bought some to put in my kit but, I'm not too sure about them to be honest. It's been discussed in the past:

My method of taking SN without vomiting

Hello everyone, I'm with you again with my ideas. My condition is very bad, I will be laconic, but you will understand me, I'm sorry. Thanks to this forum and you, I learned about SN, now I am carefully working on this method. He's my priority. I had an idea, never seen before, why not seal SN...

sanctioned-suicide.net

 

[ChefTesta]

I have bought some to put in my kit but, I'm not too sure about them to be honest. It's been discussed in the past:

My method of taking SN without vomiting

Hello everyone, I'm with you again with my ideas. My condition is very bad, I will be laconic, but you will understand me, I'm sorry. Thanks to this forum and you, I learned about SN, now I am carefully working on this method. He's my priority. I had an idea, never seen before, why not seal SN...

sanctioned-suicide.net

Thank you for this, haven't read that thread before. So many people it seems try to tell you not to try this method, but I really don't give a shit. I also don't care that it might take longer or be more uncomfortable. I just don't want to throw up or taste the SN. I've seen that it can take as little as 5g of SN to be successful, and if you take 25g of SN capsules, I am confident it will still take hold and work. I don't give a flying fuck what people think or tell me what to do, still gonna give it a go :p

 

[Peter Skellern]

Thank you for this, haven't read that thread before. So many people it seems try to tell you not to try this method, but I really don't give a shit. I also don't care that it might take longer or be more uncomfortable. I just don't want to throw up or taste the SN. I've seen that it can take as little as 5g of SN to be successful, and if you take 25g of SN capsules, I am confident it will still take hold and work. I don't give a flying fuck what people think or tell me what to do, still gonna give it a go :p

If people read the FunkyGibbon thread he took the SN in standard geletin capsules - that presumably opened in his stomach. He almost died. Indeed, he would have done if a neighbour hadn't have called an ambulance. He didn't taste the SN (obviously) and didn't throw up. He puts the later down to an anti psychotic med he was on though - Chlorpromazine.

Obviously there are concerns re the Entric capsules. However, standard Geletin capsules seemingly still works as an idea.

 

[Peter Skellern]

For those interested in the capsule idea even simple Gelatin capsules to get past the SN taste, I thought I'd put this up...

 

[Eudaimonic]

I am intrigued by this idea, but how would one time the benzos so that they passed out at the right time and for long enough? And how would you know, ahead of time, how long the capsules took to release?

 

[Peter Skellern]

A mixture of long and short-term Benzo's could be taken. The capsules will arguably be in the 2-6 hour range - I imagine with an emptyish stomach.

 

[stockyman]

My question is, would anitemetics still be needed? I already used up all my legit ones unfortunately, so do you guys think OTC ones like Dramamine, Pepto-Bizmol and Emetrol would be sufficient?

or gravol? any of these work? incl dramamine, pepto?

 

[SchrodingerIsDed]

This is

I would imagine they'll be absorbed via the intestines exactly as other medication is ingested via that method. Taking medication via Enteric Capsules is hardly a new approach. The science of it is well established.

"The time required for an enteric-coated dosage form to reach the intestine mostly depends on the presence and type of food in the stomach. It varies from 30 minutes up to 7 hours, with an average time of 6 hours." I would think with an empty stomach it will be at the quicker end.

It is an interesting thing. Maybe one could employ both techniques. This one first to avoid the stomach irritation, followed by the liquid and doze-offs if you catch my meaning an hour later or something. Still, I would also be concerned that the capsules may degrade at varying rates leading to an extended and overly painful experience.

Because the contents are intended to be released in the intestines, there may be a delay in the onset of action compared to liquid forms. This could lead to a slower delivery of the medication. Enteric capsules can degrade at different rates based on factors such as the capsule material, the pH of the gastrointestinal environment, and the presence of any digestive enzymes. If the dissolution of the enteric capsule is variable, it can lead to inconsistent release rates of the medication, potentially diminishing the effectiveness.

If an enteric capsule does not dissolve quickly enough or if it takes longer to reach the intestinal environment, the onset of effects may be delayed, which might not provide the "full blast" of the medication all at once. That could be the worst outcome possible.

 

[Peter Skellern]

This is

It is an interesting thing. Maybe one could employ both techniques. This one first to avoid the stomach irritation, followed by the liquid and doze-offs if you catch my meaning an hour later or something. Still, I would also be concerned that the capsules may degrade at varying rates leading to an extended and overly painful experience.

Because the contents are intended to be released in the intestines, there may be a delay in the onset of action compared to liquid forms. This could lead to a slower delivery of the medication. Enteric capsules can degrade at different rates based on factors such as the capsule material, the pH of the gastrointestinal environment, and the presence of any digestive enzymes. If the dissolution of the enteric capsule is variable, it can lead to inconsistent release rates of the medication, potentially diminishing the effectiveness.

If an enteric capsule does not dissolve quickly enough or if it takes longer to reach the intestinal environment, the onset of effects may be delayed, which might not provide the "full blast" of the medication all at once. That could be the worst outcome possible.

25mg isn't needed though. The fatal dose is in fact far less. I believe 2-5mg is fatal. With approximately 18 capsules I'm sure enough will disolve in a timely manner.

And the whole point is to avoid the taste and the vomiting so to do both would be silly.

 

[SchrodingerIsDed]

25mg isn't needed though. The fatal dose is in fact far less. I believe 2-5mg is fatal. With approximately 18 capsules I'm sure enough will disolve in a timely manner.

And the whole point is to avoid the taste and the vomiting so to do both would be silly.

Yeah. I mean. It'd be worth some study. It's a good idea. It just doesn't have the same reliability measure of liquid due to the lack of study cases. The vomiting is definitely an issue, but overall its been proven to be highly reliable, regardless.

 

[Whale_bones]

What do you think regarding my post in the other thread? Have you gotten any answers about nausea/vomiting signals being sent from the intestines via the enteric nervous system? The capsules thing is interesting to me, I just need more answers and don't have the medical knowledge to understand it all myself.

 

[Peter Skellern]

What do you think regarding my post in the other thread? Have you gotten any answers about nausea/vomiting signals being sent from the intestines via the enteric nervous system? The capsules thing is interesting to me, I just need more answers and don't have the medical knowledge to understand it all myself.

No I haven't unfortunately.

 

[Whale_bones]

No I haven't unfortunately.

Thanks for the response anyways, I'm crossing my fingers the nurses/doctors/medical people of SaSu will stumble across one of these threads and help us out!

 

[Peter Skellern]

Thanks for the response anyways, I'm crossing my fingers the nurses/doctors/medical people of SaSu will stumble across one of these threads and help us out!

Typically not in my experience. This forum rarely ventures beyond the party line.

 

[waitin2go]

Back to feeling optimistic about raw-doggin (taking just SN; minus the protocol); apparently you can also make your own coating (I tried looking online for ready made ones but I guess they're not as popular in my region

Dropping it here: [confectionery glaze as enteric coating]

there's no data.

... until there is lots of people here plan to volunteer as tribute (myself too if I can hold on to my ctb optimism long enough and not succumb to SI)

 

[be or not to be]

Gracias por la respuesta de todos modos, estoy cruzando los dedos para que las enfermeras/médicos/personal médico de SaSu se topen con uno de estos hilos y nos ayuden.

Gracias por la respuesta de todos modos, estoy cruzando los dedos para que las enfermeras/médicos/personal médico de SaSu se topen con uno de estos hilos y nos ayuden.

 

[Esc9434]

I'm not encouraging this... However, I'm putting this out here for everyone else...

Taking a ginger root pill (500 mg) immediately after eating a piece of food empties your stomach.

It has a natural protease. You can try it yourself with FOOD.

It does exactly what you are looking for without all this other bs.

I'm NOT pushing for this to be used in the SN protocol.

If you want to experiment, then that is on you. Do it at your own risk.

 

[Whale_bones]

@be or not to be Not sure if you meant to reply to me, you just quoted my comment twice.

Taking a ginger root pill (500 mg) immediately after eating a piece of food empties your stomach.

Any source for this? The most I can find is a study saying the gastric emptying time was faster with 1200 mg of ginger capsules than with a placebo. I don't think it's accurate to say it "empties your stomach", nor would ginger capsules have any way of causing the SN to bypass the stomach in the first place.

 

[Esc9434]

@be or not to be Not sure if you meant to reply to me, you just quoted my comment twice.



Any source for this? The most I can find is a study saying the gastric emptying time was faster with 1200 mg of ginger capsules than with a placebo. I don't think it's accurate to say it "empties your stomach", nor would ginger capsules have any way of causing the SN to bypass the stomach in the first place.

The source is me.

Let's say I use this everyday due to a health issue.

Feel free to buy regular ginger root capsules and try it yourself with a small snack or at different portions of meal. Get regular ginger root, not ginger root extract.

 

[Whale_bones]

The source is me.

Let's say I use this everyday due to a health issue.

Feel free to buy regular ginger root capsules and try it yourself with a small snack or at different portions of meal. Get regular ginger root, not ginger root extract.

If you're saying that it speeds up gastric emptying, that makes sense, and is even supported by that study. However, I do not think it "empties the stomach" or mimics the effects of enteric capsules.

AFAIK, there's no way for anyone to assess on their own the precise moment when all food/material has exited the stomach and entered the small intestine. The timing in that study was assessed via ultrasound, and even then they assessed the gastric half-emptying time, because digestion is an ongoing process with many steps. The half-emptying time for a small bowl of soup was around 13 minutes with ginger capsules versus around 26 minutes without, so a significantly shorter time, but definitely not an immediate or full emptying of the stomach.