Amitriptyline OD - How much

[Emily_Numb]

I've managed to get hold of 3090mg of Amitriptyline.

Does anyone know the lethal dose for it. I keep reading various amounts.

 

[HelloHell]

PPeH 2020 stated the lethal dose is 8-10 gm

 

[Emily_Numb]

PPeH 2020 stated the lethal dose is 8-10 gm

That sounds like an awful lot. I was under the impression that it was 30mg per kg of weight.

 

[BLUE1970]

The potentially lethal dose (with desipramine, imipramine, or amitriptyline) is as low as 15 mg/kg https://emedicine.medscape.com/article/819204-
clinical

Doses of less than 20 mg/kg are unlikely to be fatal or cause severe complications but individual variation in absorption, protein binding and metabolism limit any meaningful prediction. https://emj.bmj.com/content/18/4/236

A 1974 level 4 report of 60 children hospitalized for a one-time TCA poisoning estimated the minimum lethal dose of amitriptyline or imipramine to be 30 mg/kg, although the authors included the case of a 2½- year-old child who died within 4 hours of ingesting 15 mg/ kg.. Life-threatening symptoms in adults are often seen with TCA doses in excess of 1000 mg. https://www.tandfonline.com/doi/pdf/10.1080/15563650701226192

 

[Emily_Numb]

The potentially lethal dose (with desipramine, imipramine, or amitriptyline) is as low as 15 mg/kg https://emedicine.medscape.com/article/819204-
clinical

Doses of less than 20 mg/kg are unlikely to be fatal or cause severe complications but individual variation in absorption, protein binding and metabolism limit any meaningful prediction. https://emj.bmj.com/content/18/4/236

A 1974 level 4 report of 60 children hospitalized for a one-time TCA poisoning estimated the minimum lethal dose of amitriptyline or imipramine to be 30 mg/kg, although the authors included the case of a 2½- year-old child who died within 4 hours of ingesting 15 mg/ kg.. Life-threatening symptoms in adults are often seen with TCA doses in excess of 1000 mg. https://www.tandfonline.com/doi/pdf/10.1080/15563650701226192

Thanks for your response. I get that people always refer to the PPH or whatever it's called but 8mg from what I've read is absolute overkill, unless you weigh about 300lbs

 

[Mm80]

Thanks for your response. I get that people always refer to the PPH or whatever it's called but 8mg from what I've read is absolute overkill, unless you weigh about 300lbs

I think taking them with benzos helps too emily.